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M9460665.TXT
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1994-06-25
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Document 0665
DOCN M9460665
TI Differences in IL-2 receptor levels between mycosis fungoides and
cutaneous type adult T-cell leukemia/lymphoma in the early stages of the
disease.
DT 9408
AU Oishi M; Johno M; Ono T; Honda M; Laboratory of Immunology, National
Institute of Health, Tokyo,; Japan.
SO J Invest Dermatol. 1994 May;102(5):710-5. Unique Identifier : AIDSLINE
MED/94231025
AB Skin lesions in mycosis fungoides (MF) and cutaneous-type adult T-cell
leukemia/lymphoma (c-ATL) are sometimes difficult to differentiate. Our
previous investigations showed that the alpha-chain of interleukin-2
receptor (IL-2R alpha) secretion is enhanced in both acute and chronic
type ATL. This finding suggested increased levels of IL-2R alpha in
c-ATL that might differentiate it from MF. In this study, we report
several observations on IL-2R alpha levels in MF and c-ATL. 1) Plasma
levels of IL-2R alpha determined by enzyme-linked immunosorbent assay
were higher in patients with c-ATL (tumor group, 17,571 +/- 5,919 U/ml;
non-tumor group, 4,546 +/- 1,788 U/ml) than those of patients with MF
(tumor group, 2,352 +/- 861 U/ml; plaque group, 530 +/- 174 U/ml). 2)
The percentages of IL-2R alpha-positive cells in skin lesions of c-ATL
were 30.5 +/- 13.4% in the non-tumor group and 62.7 +/- 12.0% in the
tumor group, which were significantly higher than those of MF, plaque
group (12.7 +/- 5.9%), and tumor group (3.4 +/- 2.3%). 3) Further, there
was a significant correlation between plasma IL-2R alpha levels and the
number of IL-2R alpha-positive cells in skin lesions in patients with
c-ATL (r = 0.654, p < 0.0001) and MF (r = 0.537, p < 0.01) on an
individual basis; whereas no increased IL-2R alpha levels in peripheral
blood mononuclear cells were observed in patients with either MF or
c-ATL. 4) Skin lesions of c-ATL had much higher levels of IL-2R alpha
genomic RNA than those of MF in their initial stages when measured by
DNase/reverse transcription/polymerase chain reaction and liquid
hybridization analysis. These findings suggest that increased plasma
IL-2R alpha levels in patients with either MF or c-ATL may be linked to
cellular IL-2R alpha levels in the skin lesions, and thus reflect the
difference between MF and c-ATL.
DE Adult Aged Female Human Leukemia-Lymphoma, T-Cell, Acute,
HTLV-I-Associated/BLOOD/ *METABOLISM Leukocytes, Mononuclear/CHEMISTRY
Male Middle Age Mycosis Fungoides/BLOOD/*METABOLISM Polymerase Chain
Reaction/METHODS Receptors, Interleukin-2/*ANALYSIS/GENETICS RNA,
Messenger/ANALYSIS Skin Neoplasms/*CHEMISTRY Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).